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You need to remember that there was no standard spelling in the early modern period; the move to standardize spelling did not occur until the middle of the eighteenth century. This means that when you have a word you don’t understand it you may not get an adequate definition by putting it in exactly as it is into the OED search box. Try that first but if it isn’t found, or you get a definition that is not right (. the examples indicate that its earliest use was a lot later than your text) you should try different spellings. In particular the vowels are often interchangeable. Try every vowel combination that you can think of. Try substituting ts and cs, us and vs and other related consonants.
Example: Imagine that you want to write a descriptive essay about your grandfather. You've chosen to write about your grandfather's physical appearance and the way that he interacts with people. However, rather than providing a general description of these aspects, you want to convey your admiration for his strength and kindness. This is your reason for writing the descriptive essay. To achieve this, you might focus one of your paragraphs on describing the roughness of his hands, roughness resulting from the labor of his work throughout his life, but you might also describe how he would hold your hands so gently with his rough hands when having a conversation with you or when taking a walk.